Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox9  SRY (sex determining region Y)-box 9   (Synonyms: 2010306G03Rik)
Results	Reference
1*	J:324263 Aksel S, Cao M, Derpinghaus A, Baskin LS, Cunha GR, Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from embryonic day 10 to adulthood. Differentiation. 2022 Mar 7;
1	J:150973 Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP, Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009 Jun;136(7):2325-33
1	J:190736 Balczerski B, Zakaria S, Tucker AS, Borycki AG, Koyama E, Pacifici M, Francis-West P, Distinct spatiotemporal roles of hedgehog signalling during chick and mouse cranial base and axial skeleton development. Dev Biol. 2012 Nov 15;371(2):203-14
1*	J:110714 Barrionuevo F, Taketo MM, Scherer G, Kispert A, Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 Jul 1;295(1):128-40
1	J:189073 Benazet JD, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R, Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development. 2012 Nov;139(22):4250-60
1	J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
1	J:110914 Bommireddy R, Ormsby I, Yin M, Boivin GP, Babcock GF, Doetschman T, TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol. 2003 Apr 1;170(7):3645-52
1*	J:93163 Boulet AM, Moon AM, Arenkiel BR, Capecchi MR, The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 2004 Sep 15;273(2):361-72
1	J:289977 Carpinelli MR, de Vries ME, Auden A, Butt T, Deng Z, Partridge DD, Miles LB, Georgy SR, Haigh JJ, Darido C, Brabletz S, Brabletz T, Stemmler MP, Dworkin S, Jane SM, Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure. Dis Model Mech. 2020 Jan 31;:dmm042218
1	J:213873 Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC, FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development. 2014 Jul;141(13):2691-701
1*	J:337818 Currie JD, Grosser L, Murawala P, Schuez M, Michel M: Tanaka EM, Sandoval-Guzman T, The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts. Biol Open. 2019;8(7):bio043711
1	J:304767 Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA, Med23 Regulates Sox9 Expression during Craniofacial Development. J Dent Res. 2021 Apr;100(4):406-414
1	J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104
1	J:264144 Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ, A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7:e34110
1	J:338937 Farley AM, Chengrui A, Palmer S, Liu D, Kousa AI, Rouse P, Major V, Sweetman J, Morys J, Corsinotti A, Nichols J, Ure J, McLay R, Boulter L, Chapman SJ, Tomlinson SR, Blackburn CC, Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis. Front Immunol. 2023;14:1202163
1	J:327525 Fuglerud BM, Drissler S, Lotto J, Stephan TL, Thakur A, Cullum R, Hoodless PA, SOX9 reprograms endothelial cells by altering the chromatin landscape. Nucleic Acids Res. 2022 Aug 26;50(15):8547-8565
1*	J:294694 Furusawa T, Lim JH, Catez F, Birger Y, Mackem S, Bustin M, Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes. Mol Cell Biol. 2006 Jan;26(2):592-604
1	J:308974 Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J, Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development. Theranostics. 2021;11(9):4316-4334
1	J:214089 Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ, The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
1	J:243204 Han L, Xu J, Grigg E, Slack M, Chaturvedi P, Jiang R, Zorn AM, Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Dev Biol. 2017 Jul 01;427(1):72-83
1	J:309374 Haraguchi R, Kitazawa R, Kitazawa S, Epigenetic regulation of Tbx18 gene expression during endochondral bone formation. Cell Tissue Res. 2015 Feb;359(2):503-512
1	J:342844 Harvey AB, Wolters RA, Deepe RN, Tarolli HG, Drummond JR, Trouten A, Zandi A, Barth JL, Mukherjee R, Romeo MJ, Vaena SG, Tao G, Muise-Helmericks R, Ramos PS, Norris RA, Wessels A, Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development. J Mol Cell Cardiol. 2023 Nov 5;186:16-30
1	J:276709 Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K, Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos. Genes Cells. 2019 Jun;24(6):436-448
1	J:203056 Hines EA, Jones MK, Verheyden JM, Harvey JF, Sun X, Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19444-9
1	J:267950 Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH, HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. Int J Dev Biol. 2018;62(11-12):785-796
1	J:281226 Huang X, Feng T, Jiang Z, Meng J, Kou S, Lu Z, Chen W, Lin CP, Zhou B, Zhang H, Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes. J Biol Chem. 2019 May 31;294(22):8894-8906
1	J:188394 Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B, Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12;74(1):79-94
1*	J:237224 Kim JY, Park R, Lee JH, Shin J, Nickas J, Kim S, Cho SH, Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347
1	J:123924 Kim TH, Goodman J, Anderson KV, Niswander L, Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell. 2007 Jul;13(1):87-102
1	J:235727 Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, Crespo-Enriquez I, Evans P, Balczerski B, Mankoo B, Irvine KD, Francis-West PH, Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 2016 Jul 1;143(13):2367-75
1	J:290226 Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO, Delineating the early transcriptional specification of the mammalian trachea and esophagus. Elife. 2020 Jun 9;9:e55526
1	J:200546 Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F, Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS One. 2013;8(5):e63143
1	J:254771 Larsen HL, Martin-Coll L, Nielsen AV, Wright CVE, Trusina A, Kim YH, Grapin-Botton A, Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis. Nat Commun. 2017 Sep 19;8(1):605
1	J:308018 Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV, Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Dev Dyn. 2021 Jul;250(7):1001-1020
1	J:293339 Liang S, Johansson E, Barila G, Altschuler DL, Fagman H, Nilsson M, A branching morphogenesis program governs embryonic growth of the thyroid gland. Development. 2018 Jan 25;145(2):dev146829
1	J:333209 Liang Y, Song C, Li J, Li T, Zhang C, Zou Y, Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice. BMC Genomics. 2023 Feb 9;24(1):68
1*	J:321069 Lopez-Marquez A, Carrasco-Lopez C, Martinez-Cano A, Lemoine P, Pierreux CE, Santisteban P, Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFbeta and thyroid transcription factors. Sci Rep. 2022 Feb 9;12(1):2144
1	J:340446 Lotto J, Cullum R, Drissler S, Arostegui M, Garside VC, Fuglerud BM, Clement-Ranney M, Thakur A, Underhill TM, Hoodless PA, Cell diversity and plasticity during atrioventricular heart valve EMTs. Nat Commun. 2023 Sep 9;14(1):5567
1*	J:122373 Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS, Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10500-5
1	J:229604 Machon O, Masek J, Machonova O, Krauss S, Kozmik Z, Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
1*	J:150757 Mak AC, Szeto IY, Fritzsch B, Cheah KS, Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development. Gene Expr Patterns. 2009 Sep;9(6):444-53
1	J:267771 Mamidi A, Prawiro C, Seymour PA, de Lichtenberg KH, Jackson A, Serup P, Semb H, Mechanosignalling via integrins directs fate decisions of pancreatic progenitors. Nature. 2018 Dec;564(7734):114-118
1	J:225823 Martin D, Kim YH, Sever D, Mao CA, Haefliger JA, Grapin-Botton A, REST represses a subset of the pancreatic endocrine differentiation program. Dev Biol. 2015 Sep 15;405(2):316-27
1	J:274906 McGlinn E, Holzman MA, Mansfield JH, Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections. Methods Mol Biol. 2019;1920:183-218
1	J:266575 Metzler MA, Raja S, Elliott KH, Friedl RM, Tran NQH, Brugmann SA, Larsen M, Sandell LL, RDH10-mediated retinol metabolism and RARalpha-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018 Aug 2;145(15):dev164822
1*	J:118793 Nakanishi K, Chan YS, Ito K, Notch signaling is required for the chondrogenic specification of mouse mesencephalic neural crest cells. Mech Dev. 2007 Mar;124(3):190-203
1	J:230332 Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K, Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Genes Cells. 2015 Jun;20(6):500-11
1*	J:38926 Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E , Bell DM , Tam PP , Cheah KS , Koopman P, SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol. 1997 Mar 1;183(1):108-21
1	J:176531 Nowakowski TJ, Mysiak KS, Pratt T, Price DJ, Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One. 2011;6(8):e23013
1	J:303312 Rayon T, Stamataki D, Perez-Carrasco R, Garcia-Perez L, Barrington C, Melchionda M, Exelby K, Lazaro J, Tybulewicz VLJ, Fisher EMC, Briscoe J, Species-specific pace of development is associated with differences in protein stability. Science. 2020 Sep 18;369(6510)
1*	J:278228 Reinhardt R, Gullotta F, Nusspaumer G, Unal E, Ivanek R, Zuniga A, Zeller R, Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling. Development. 2019 May 28;146(10):dev173328
1	J:202984 Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR, Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
1	J:247121 Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ, HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci. 2016 Jun 01;129(11):2145-55
1	J:338817 Schoultz E, Liang S, Carlsson T, Filges S, Stahlberg A, Fagman H, Wiel C, Sayin V, Nilsson M, Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage factor. iScience. 2023 Jul 21;26(7):107071
1	J:165253 Scott CE, Wynn SL, Sesay A, Cruz C, Cheung M, Gomez Gaviro MV, Booth S, Gao B, Cheah KS, Lovell-Badge R, Briscoe J, SOX9 induces and maintains neural stem cells. Nat Neurosci. 2010 Oct;13(10):1181-9
1	J:297252 Seymour PA, Collin CA, Egeskov-Madsen AR, Jorgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P, Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020 Mar 23;52(6):731-747.e8
1	J:119758 Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M, SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1865-70
1	J:187729 Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M, A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep;139(18):3363-72
1*	J:273053 Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M, A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13;13(2):326-36
1	J:84301 Stolt CC, Lommes P, Sock E, Chaboissier MC, Schedl A, Wegner M, The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003 Jul 1;17(13):1677-89
1*	J:98585 Stolt CC, Schmitt S, Lommes P, Sock E, Wegner M, Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol. 2005 May 15;281(2):309-17
1	J:205050 Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM, Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Development. 2013 Nov;140(22):4574-82
1	J:242317 Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG, Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4
1*	J:138770 Ten Berge D, Brugmann SA, Helms JA, Nusse R, Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development. 2008 Oct;135(19):3247-57
1	J:311908 Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M, Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia. 2020 May;68(5):932-946
1	J:233479 Vong KI, Leung CK, Behringer RR, Kwan KM, Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25
1	J:330212 Wang S, Tanaka Y, Xu Y, Takeda S, Hirokawa N, KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice. Dev Cell. 2022 Oct 10;57(19):2273-2289.e11
1	J:325905 Willnow D, Benary U, Margineanu A, Vignola ML, Konrath F, Pongrac IM, Karimaddini Z, Vigilante A, Wolf J, Spagnoli FM, Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche. Nature. 2021 Sep;597(7874):87-91
1	J:138651 Yoshida T, Shiraki N, Baba H, Goto M, Fujiwara S, Kume K, Kume S, Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas. Genes Cells. 2008 Jul;13(7):667-78
1	J:243987 Zalc A, Rattenbach R, Aurade F, Cadot B, Relaix F, Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell. 2015 Apr 06;33(1):56-66
1*	J:170393 Zhang Q, Cigan AD, Marrero L, Lopreore C, Liu S, Ge D, Savoie FH, You Z, Expression of doublecortin reveals articular chondrocyte lineage in mouse embryonic limbs. Genesis. 2011 Feb;49(2):75-82